Home General Physiology and Biophysics 2023 General Physiology and Biophysics Vol.42, No.5, p. 403–415, 2023

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Founded: 1982
ISSN 1338-4325 (online)
ISSN 0231-5882 (print)
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General Physiology and Biophysics Vol.42, No.5, p. 403–415, 2023

Title: Correlation of microsatellite status and EBV infection with clinical characteristics of patients with gastric cancer
Author: Pengfei Lu, Kadeliya Yushan, Gulimilai Yusufu, Hui Wang, Rui Mao
Abstract: This study was designed to investigate the correlation of microsatellite status (MS) and Epstein-Barr virus (EBV) infection with the clinical characteristics of gastric cancer (GC) patients. MS was detected by immunohistochemistry. EBV was detected by in situ hybridization. There were 31.3% cases showed mismatch repair-deficient (dMMR)/ microsatellite instability (MSI) and 68.7% cases showed mismatch repair-proficient (pMMR)/ microsatellite stability (MSS). The dMMR/MSI was more common in the elderly, in patients with cardia GC, smaller tumor diameter or non-poorly differentiated carcinoma. The survival in dMMR/MSI patients tended to be longer than that in pMMR/MSS patients. Total 7.6% cases showed EBV-positive (EBV(+)) among 198 GC patients. EBV(+) was more common in patients with advanced GC or poorly differentiated adenocarcinoma. MSI was more common in EBV-negative (EBV(−)) patients than in EBV(+) patients. The dMMR/MSI patients with stage II GC benefited from chemotherapy. The survival of EBV(+) patients tended to be longer than that of EBV(−) patients
Keywords: Gastric cancer — Microsatellite status — EBV — Clinicopathological parameters — Survival prognosis
Published online: 19-Sep-2023
Year: 2023, Volume: 42, Issue: 5 Page From: 403, Page To: 415
doi:10.4149/gpb_2023021


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