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Bratislava Medical Journal 2023 Bratislava Medical Journal Vol.124, No.10, p.768–773, 2023
Bratislava Medical Journal 2023 Bratislava Medical Journal Vol.124, No.10, p.768–773, 2023
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Bratislava Medical Journal Vol.124, No.10, p.768–773, 2023 |
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| Title: Comparison of effects of quercetin and ascorbic acid on inflammatory cytokines and antioxidant biomarkers in infant rats using an experimental sepsis model | ||
| Author: Emine Ufuk BOZKURT, Abdulrahman OZEL, Meltem EROL, Aslihan TENEKECIGIL, Ozlem BOSTAN GAYRET, Ovgü BUKE, Volkan TOSUN | ||
| Abstract: OBJECTIVE: There is ongoing research on treatments that promote antioxidant and anti-inflammatory mechanisms, which will reduce mortality in sepsis. In this study, we compared the anti-inflammatory and antioxidant activities of quercetin and ascorbic acid using a sepsis model induced in infant rats. METHODS: A total of 28 infant rats 21-days-old that had just completed the lactation period were divided into four groups: control, sepsis, sepsis + quercetin, and sepsis + ascorbic acid. The sepsis model was created with an intraperitoneal injection of bacterial lipopolysaccharide. After 24 hours, blood samples were collected for analysis of serum levels of inflammatory cytokines (IL-1β, IL-6, TNF-α, and CRP) and antioxidants (CAT, GPx, SOD, and GST). RESULTS: The superoxide dismutase levels were significantly higher in the sepsis + ascorbic acid group compared to the sepsis and sepsis + quercetin groups. The levels of the most active cytokines in sepsis were significantly lower in the serum samples of the septic subjects who received quercetin and ascorbic acid. CONCLUSION: The antioxidant activity, which is impaired in sepsis, was increased by both molecules. We observed that these two molecules, which are free of side effects, have a positive influence on the progression of sepsis to severe and fatal sepsis in childhood (Tab. 2, Ref. 38). |
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| Keywords: antioxidants, ascorbic acid, quercetin, sepsis, cytokines, infant rats. | ||
| Published online: 19-Sep-2023 | ||
| Year: 2023, Volume: 124, Issue: 10 | Page From: 768, Page To: 773 | |
| doi:10.4149/BLL_2023_118 |
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