Home Bratislava Medical Journal 2023 Bratislava Medical Journal Vol.124, No.10, p.779–782, 2023

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

Impact factor 1.564


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Bratislava Medical Journal Vol.124, No.10, p.779–782, 2023

Title: The frequency of, and predisposing risk factors for, ciprofloxacin-induced neuro-psychiatric adverse drug reactions
Author: Jan Miroslav HARTINGER, Eliska DVORACKOVA, Marek MYSLIVECEK, Zdenka HRUSKOVA, Martin SATNY, Lukas ZLATOHLAVEK, Jarmila KRIZOVA, Martin SIMA, Vladimir TESAR, Ondrej SLANAR

Abstract: OBJECTIVES: Ciprofloxacin induces rare neuro-psychiatric adverse drug reactions (ADRs) that are, as yet, not possible to predict due to unknown predisposition factors.
BACKGROUND: The aim of the analysis was to assess the frequency of neuro-psychiatric ADRs and to identify potential risk factors that predisposed patients to ciprofloxacin neurotoxicity.
METHODS: This observational retrospective study involved the evaluation of the medical records of patients in the Nephrology department and 3rd Internal Clinic of the General University Hospital in Prague.
RESULTS: The overall incidence of neurological ADRs was 3.6 %. No neurological ADRs developed in patients aged less than 70 years. The covariates that were significantly more prevalent in the patients who developed neuropsychiatric ADRs were as follows: higher age, a history of neuropsychiatric disorders and the use of anticonvulsants. The administration of drugs from other ATC groups, gender, weight, body mass index, body surface area, renal functions, level of C-reactive protein at the beginning of treatment and the total daily dose/kg did not differ significantly between the two groups.
CONCLUSION: Ciprofloxacin neuropsychiatric ADRs are more frequent in older patients with a history of neurologic or psychiatric disorders. No other tested covariates were proven to predispose patients to neuropsychiatric ADRs during treatment with ciprofloxacin (Tab. 2, Ref. 20).

Keywords: fluoroquinolones, delirium, neurotoxicity, kidney disease, infection
Published online: 12-Sep-2023
Year: 2023, Volume: 124, Issue: 10 Page From: 779, Page To: 782

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