Home Bratislava Medical Journal Ahead of print Bratislava Medical Journal Vol.125, No.1, p.17–23, 2024

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

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Bratislava Medical Journal Vol.125, No.1, p.17–23, 2024

Title: Distribution and relevance of hepatitis B genotypes in the general population of Slovakia
Author: Ivana HockickovA, Elena HatalovA, Jakub Gazda, Patricia Denisa LenArtovA, Martin JaniCko, Peter JarCuSka, Sylvia DraZilovA, Maria Logoida, Monika HalAnova, Ivan SchrEter, Pavol Kristian

Abstract: AIMS: The aim of the presented study was to determine the distribution of HBV genotypes and their influence on selected parameters in patients in eastern Slovakia.
METHODS: The study includes 202 patients with confirmed chronic HBV infection or hepatitis. For each patient, basic demographic data, and serum samples were collected. The degree of liver fibrosis was determined by transient elastography. The obtained data were evaluated statistically.
RESULTS: Out of a total of 202 patients, 96.0 % of the patients were from the EU region and 27 patients (13.4 %) self-identified as Roma ethnic group. The most common genotype among our patients was genotype A (n = 104; 51.5 %), followed by genotype D (n = 76; 37.6 %) and A/D (n = 13; 6.4 %). In patients from the EU region, genotypes A and D predominated statistically significantly (p < 0.0001). Due to a low number of patients with other genotypes, in the subsequent analysis, we only compared patients with HBV genotypes A or D.
Patients with genotypes D and A/D significantly more often mention tattoos as a possible risk factor for disease transmission compared to patients with genotype A (p = 0.043). Subsequently, we divided patients into two groups – treated and untreated. The level of qHBsAg was significantly higher in untreated patients with genotypes A (p < 0.0001). The influence of HBV genotypes on other laboratory parameters was not confirmed in our study.
CONCLUSION: This is the first HBV genotypes study from Slovakia. We suggest that HBV genotypes may play a role in the virus-host relationship

Keywords: chronic hepatitis B, genotypes, hepatitis B virus, prognostic factors, distribution
Published online: 02-Dec-2023
Year: 2024, Volume: 125, Issue: 1 Page From: 17, Page To: 23

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