Home 
CONTACT General Physiology and Biophysics 2023 General Physiology and Biophysics Vol.42, No.6, p. 495–506, 2023
CONTACT General Physiology and Biophysics 2023 General Physiology and Biophysics Vol.42, No.6, p. 495–506, 2023
Journal info
Aims and Scope |
||
Select Journal
Journals
Bratislava Medical Journal Endocrine Regulations General Physiology and Biophysics 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 Neoplasma Acta Virologica Studia Psychologica Cardiology Letters Psychológia a patopsych. dieťaťa Kovove Materialy-Metallic Materials Slovenská hudbaWebshop Cart
Your Cart is currently empty.
Info: Your browser does not accept cookies. To put products into your cart and purchase them you need to enable cookies.
General Physiology and Biophysics Vol.42, No.6, p. 495–506, 2023 |
||
| Title: Early-life maternal deprivation in rats increases sensitivity to the subsequent stressors: a pilot study | ||
| Author: Maria Komelkova, Boris Yushkov, Stanislav Fedorov, Roman Ibragimov, Pavel Platkovskiy, Desheng Hu, Shanshan Luo, Alexey Sarapultsev | ||
| Abstract: Early life experiences, particularly maternal deprivation (MD), have long-lasting implications on emotional and cognitive development. Using Wistar rats as a model, this study explores the impact of MD followed by predator stress exposure (PSS) to simulate aspects of post-traumatic stress disorder (PTSD). A cohort of 41 male rat pups underwent MD from postnatal days 2 to 14, followed by PSS at day 90. Female rat pups were not included in the experiment. Behavior was subsequently assessed using the Elevated Plus Maze test 14 days post-PSS. While MD led to subtle changes such as decreased activity and increased anxiety-like behavior, PSS induced pronounced anxiogenic effects. Notably, PSS after MD resulted in decreased basal corticosterone levels, mirroring conditions observed in PTSD. The findings suggest that although MD itself does not induce significant behavioral changes, it predisposes individuals to heightened sensitivity to subsequent stressors. This study underscores the utility of a two-stage PSS model for more accurately reflecting the complexities inherent in stress-related disorders, including PTSD. |
||
| Keywords: Cortisol — Early life stress — Maternal deprivation — Post-traumatic stress disorder — PTSD rats — Sensitivity | ||
| Published online: 14-Nov-2023 | ||
| Year: 2023, Volume: 42, Issue: 6 | Page From: 495, Page To: 506 | |
| doi:10.4149/gpb_2023022 |
||
|
|
 download file |
|