General Physiology and Biophysics Vol.42, No.6, p. 507

General Physiology and Biophysics Vol.42, No.6, p. 507–519, 2023

Founded: 1982
ISSN 1338-4325 (online)
ISSN 0231-5882 (print)
Published in English,
6 times per year

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General Physiology and Biophysics Vol.42, No.6, p. 507–519, 2023
Title: Effects of novel mRNA-VEGF@USPIO nanoparticles on human brain microvascular endothelial cell injury
Author: Jiang Zhao, Zhiyuan Qian

Abstract: We investigated the effect of mRNA-VEGF@ultrasmall superparamagnetic iron oxide (USPIO) nanoparticles on the repair of human brain microvascular endothelial cell (HBMECs) injury and its related mechanisms. mRNA-VEGF@USPIO nanoparticles were designed, prepared, and characterized using NTA and UV spectrophotometry. Cell viability was determined using the CCK-8. Cells in the control, TNF-α, and mRNA-VEGF@USPIO groups were sequenced and the differentially expressed genes (DEGs) were identified. Finally, a functional analysis of the DEGs was performed. Both NTA and spectrophotometry results indicated that mRNA-VEGF@USPIO was successfully constructed. TNF-α significantly reduced cell viability and promoted apoptosis compared with the control group (p

Keywords: Ultrasmall superparamagnetic iron oxide — Human brain microvascular endothelial cells — Nanoparticles — Differentially expressed genes
	Published online: 14-Nov-2023
Year: 2023, Volume: 42, Issue: 6	Page From: 507, Page To: 519
doi:10.4149/gpb_2023032
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