Bratislava Medical Journal Vol.124, No.12, p.892

Bratislava Medical Journal Vol.124, No.12, p.892–895, 2023

Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

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Bratislava Medical Journal Vol.124, No.12, p.892–895, 2023
Title: The effects of local anesthetics on cancer cells
Author: Simona HUMPLIKOVA, Petra PRISCAKOVA, Vanda REPISKA

Abstract: During cancer surgery, the perioperative period is characterized by stress response and immunosuppression that can lead to further worsening of the disease and metastatic spread. Local anesthetics have antiproliferative, cytotoxic and antimetastatic effects on cancer cells in vitro. There is scientific evidence that local anesthetics possess anti-inflammatory effects, help to preserve normal immune function and reduce the possibility of metastatic spread. Anesthetic care affects pain, inflammation, and immunosuppression, which may have a great impact on the outcome of oncological patients. The use of local anesthetics during the perioperative period in oncological patients may have a beneficial effect on their survival and cancer recurrence. This article summarizes the effects of local anesthetics in vitro (Tab. 1, Fig. 1, Ref. 36).

Keywords: local anesthetics, cancer cells
	Published online: 20-Nov-2023
Year: 2023, Volume: 124, Issue: 12	Page From: 892, Page To: 895
doi:10.4149/BLL_2023_141
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