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HOME Bratislava Medical Journal 2024 Bratislava Medical Journal Vol.125, No.3, p. 166–171, 2024
HOME Bratislava Medical Journal 2024 Bratislava Medical Journal Vol.125, No.3, p. 166–171, 2024
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Bratislava Medical Journal Vol.125, No.3, p. 166–171, 2024 |
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| Title: Characterization of HIV-1 subtypes and drug resistance mutations in Slovakia: update 2017–2018 | ||
| Author: Monika HABEKOVA, Danica VALKOVICOVA STANEKOVA, Maria TAKACOVA, Alexandra KOVAROVA | ||
| Abstract: OBJECTIVES: This study aimed to provide an overview on the HIV-1 subtypes circulating in Slovakia between 2017 and 2018 and to evaluate the risk of transmission of HIV‑resistant strains. BACKGROUND: The HIV epidemic in Slovakia is characterised by low incidence of new and pre-existing infections and a slightly elevated level of strain heterogeneity. METHODS: Partial HIV pol gene sequences of 110 individuals newly diagnosed with HIV between 2017 and 2018 were analysed. RESULTS: The genotypic analysis revealed sporadic occurrence of mutations linked to HIV resistance to antiretroviral therapy (ART). The HIV-1 B subtype has been found as predominant (84.55 %) and primarily linked to men who have sex with men (MSM). A total of eighteen individuals (15.45 %) were found to be infected with HIV-1 non-B subtypes. CONCLUSION: The data suggest a minimal risk of a resistant HIV strain transmission and a marginal rise of HIV-1 subtypes´ diversity. The HIV-1 B subtype remains the most prevalent in the period 2017–2018 in Slovakia (Tab. 2, Fig. 2, Ref. 37). |
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| Keywords: HIV-1, subtypes, Slovakia, resistance, ART | ||
| Published online: 27-Dec-2023 | ||
| Year: 2024, Volume: 125, Issue: 3 | Page From: 166, Page To: 171 | |
| doi:10.4149/BLL_2024_26 |
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