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General Physiology and Biophysics 2024 General Physiology and Biophysics Vol.43, No.1, p 13–23, 2024
General Physiology and Biophysics 2024 General Physiology and Biophysics Vol.43, No.1, p 13–23, 2024
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General Physiology and Biophysics Vol.43, No.1, p 13–23, 2024 |
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| Title: Naringenin protects myocardial ischemia/reperfusion injury by regulating miR-24-3p to inhibit cell death-inducing p53 target 1 expression | ||
| Author: Xiao Jin, Ling Jin,Bingxin Wu, Danping Xu | ||
| Abstract: Myocardial ischemia/reperfusion (I/R) causes serious threats to human life. Naringenin, a polyphenolic compound naturally occurring in citrus fruit, has cardioprotective effects against myocardial I/R injury. Besides, miR-24-3p is also reported to have cardioprotective effects. We intended to explore whether the cardioprotective effects of naringenin relate to miR-24-3p and its underlying mechanism. In this study, we used an in vivo rat myocardial I/R model and an in vitro cardiomyocyte H9c2 hypoxia/reoxygenation (H/R) model. Myocardial injury was detected by hematoxylin-eosin staining and ELISA for creatine kinase (CK), malondialdehyde (MDA), and lactate dehydrogenase (LDH). miR-24-3p and cell death inducing p53 target 1 (Cdip1) mRNA expressions were examined by RT-PCR. We find that naringenin pretreatment significantly relieves myocardial I/R injury, reduces LDH, CD, and MDA levels, and increases miR-24-3p expression. Furthermore, miR-24-3p alleviates myocardial I/R injury partially through regulating Cdip1. Moreover, naringenin protects myocardial I/R injury partially by regulating miR-24-3p to inhibit Cdip1 expression. In conclusion, our data suggest naringenin protects myocardial I/R injury partially through miR-24-3p/Cdip1 axis |
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| Keywords: Myocardial ischemia/reperfusion injury — Naringenin — miR-24-3p — Cell death-inducing p53 target 1 — Apoptosis | ||
| Published online: 14-Jan-2024 | ||
| Year: 2024, Volume: 43, Issue: 1 | Page From: 13, Page To: 23 | |
| doi:10.4149/gpb_2023035 |
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