General Physiology and Biophysics Vol.43, No.1, p 25

General Physiology and Biophysics Vol.43, No.1, p 25–36, 2024

Quarterly, 80 pp. per issue
Founded: 1982
ISSN 1338-4325 (online)

Published in English

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General Physiology and Biophysics Vol.43, No.1, p 25–36, 2024
Title: Effect of quercetin administration during the first two weeks post-weaning on the development of non-alcoholic fatty liver disease and dyslipidaemia in Sprague Dawley rats fed a high fructose diet
Author: Ramatsobane Tladi, Kennedy H. Erlwanger, Janine Donaldson

Abstract: Hepatic steatosis and dyslipidaemia are associated with excessive fructose consumption. We investigated the effect of quercetin intake during the early pre-weaning period on metabolic dysfunction caused by a high fructose diet. Sprague Dawley rats, 21-day-old, were weaned onto standard rat chow and randomly allocated to four groups which either water or 20% fructose solution to drink with or without quercetin (100 mg/kg body mass). Quercetin was administered for two weeks. Thereafter, rats continued on their respective diets for six weeks without quercetin. Terminally, serum triglyceride concentrations were not significantly different (p > 0.05) between males across groups. However, females receiving quercetin alone had lower serum triglyceride levels than those receiving fructose (p

Keywords: Post-weaning — Dyslipidaemia — High-fructose diet — Phytochemicals
	Published online: 17-Jan-2024
Year: 2024, Volume: 43, Issue: 1	Page From: 25, Page To: 36
doi:10.4149/gpb_2023033
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