Home General Physiology and Biophysics 2024 General Physiology and Biophysics Vol.43, No.1, p 57–71, 2024

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Quarterly, 80 pp. per issue
Founded: 1982
ISSN  1338-4325 (online)

Published in English

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General Physiology and Biophysics Vol.43, No.1, p 57–71, 2024

Title: Combination therapy of metformin and atorvastatin against benzopyrene-induced lung cancer via inflammatory signaling pathway
Author: Xuecong Ning, Shusen Zhang, Zhiguo Gao, Aimin Li
Abstract: The most prevalent cause of lung cancer is smoking tobacco, but exposure to second hand smoke, air pollution, and certain chemicals and substances at work can also raise the risk of disease. In this study, we scrutinized the chemoprotective effect of the metformin and atorvastatin combination against benzo[a]pyrene (BaP)-induced lung cancer in mice of Swiss albino. BaP (50 mg/kg) was used for induction of lung cancer and mice were treated with metformin, atorvastatin or their combination. Metformin + atorvastatin combination significantly (p < 0.001) improved the body weight, liver weight, suppressed the lung weight and tumor incidence and altered the levels of immunocompetent cells, polyamines, lung tumor markers, lung parameters and antioxidant parameters, respectively. Metformin + atorvastatin combination also suppressed cytokines levels, inflammatory parameters and caspase parameters. On the basis of the results, we can conclude that metformin + atorvastatin combination remarkably suppressed lung cancer via the inflammatory pathway.
Keywords: Metformin — Atorvastatin — Lung cancer — Polyamine — Inflammation
Published online: 17-Jan-2024
Year: 2024, Volume: 43, Issue: 1 Page From: 57, Page To: 71
doi:10.4149/gpb_2023030


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