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Neoplasma Vol.70, No.6, p. 796–803, 2023 |
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| Title: Favorable prognostic significance of membranous β-catenin expression and negative prognostic significance of cytoplasmic β-catenin expression in pancreatic cancer | ||
| Author: Blanka Rosova, Jan Proks, Alzbeta Filipova, Dimitar Hadzi Nikolov, Renata Chloupkova, Igor Richter, Arpad Szabo, Aneta Rozsypalova, Radoslav Matej, Bohuslav Melichar, Tomas Buchler, Josef Dvorak | ||
| Abstract: The aim of this study was to investigate the prognostic significance of membranous β-catenin and cytoplasmic β-catenin expression in pancreatic cancer patients (pts). One hundred pts with histologically verified exocrine pancreatic ductal adenocarcinoma were retrospectively studied. The membranous β-catenin, cytoplasmic β-catenin, and cell nucleus β-catenin expression were immunohistochemically evaluated. The expression of membranous β-catenin was 75% in 81 pts. The expression of cytoplasmic β-catenin was 75% in one patient. The expression of β-catenin in the cell nucleus was negative in all pts. At the time of the last follow-up, 21 pts were alive and 79 pts had died. Median OS was 1.3 (0.4–2.3) years in pts with membranous β-catenin expression ≤75% and 1.7 (1.3–2.1) years in pts with membranous β-catenin expression >75% (p=0.045). Median OS was (1.3–2.0) 1.6 years in pts with cytoplasmic β-catenin expression ≤25% and 0.9 (0.5–1.2) years in pts with cytoplasmic β-catenin expression >25% (p=0.040). In the univariate Cox proportional hazard models HR (95% CI) was 0.556 (0.311–0.995) in pts with membranous β-catenin expression >75% (p=0.048) and 2.200 (1.216–3.980) in pts with cytoplasmic β-catenin expression >25% (p=0.009). The present results indicate a favorable prognostic significance of membranous β-catenin expression in pancreatic cancer. |
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| Keywords: β-catenin cytoplasmic; β-catenin membranous; CD8+ tumor infiltrating lymphocytes; pancreatic ductal adenocarcinoma; primary cilia; programmed cell death protein 1 | ||
| Published online: 19-Jan-2024 | ||
| Year: 2023, Volume: 70, Issue: 6 | Page From: 796, Page To: 803 | |
| doi:10.4149/neo_2023_230721N380 |
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