Home Bratislava Medical Journal 2024 Bratislava Medical Journal Vol.125, No.4, p.233–238, 2024

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

Impact factor 1.564

 

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Bratislava Medical Journal Vol.125, No.4, p.233–238, 2024

Title: Telomerase activity and hTERT gene expression in patients with acute coronary syndrome and stable coronary artery disease
Author: Mehmet KILINC, Oguz KILIC, Mucahit SECME, Cihan Ilyas SEVGICAN, Ibrahim OGUZ, Hande SENOL, Yavuz DODURGA, Gokay NAR, Ismail Dogu KILIC
Abstract: BACKGROUND: In this study, we aimed to examine the telomerase activity and hTERT gene expression in patients with acute coronary syndrome (ACS) and those with stable coronary artery disease (SCAD) and compare the results to controls. Additionally, we compared overall mortality rates relative to the telomerase activity.
METHODS: A total of 211 patients (78 ACS and 71 SCAD patients) were included in the study. The telomerase concentration was measured by ELISA and used to determine telomerase activity. The hTERT gene expression was determined by real-time PCR.
RESULTS: The serum telomerase enzyme concentration was lower in ACS (36.61 ± 1.54) and SCAD (36.79 ± 1.57) when compared to the control group (37.03 ± 2.25). However, this difference did not reach statistical significance (p = 0.890). The hTERT gene expression acting in telomerase enzyme synthesis was 2.7-fold lower in ACS group (p = 0.070) and 2.2-fold lower in the SCAD group (p = 0.101) compared to the control group. Patients were followed for a median of 32 months (minimum: 0.1, maximum: 46.8). The serum telomerase concentrations in patients who died and those survived in the SCAD group (35.98 ± 2.02 vs 36.86 ± 1.52 ng/ml, respectively; p = 0.529) were similar to those in the ACS group (36.39 ± 1.08 vs 36.63 ± 1.60 ng/ml, respectively p = 0.993).
CONCLUSIONS: In the current study, telomerase activity or hTERT expression was similar in patients with ACS, SCAD, and controls. Moreover, telomerase activity was not associated with all- cause mortality during the 32-month follow-up (Tab. 3, Fig. 1, Ref. 29).
Keywords: acute coronary syndrome, coronary artery disease, hTERT gene expression, stable coronary artery, telomerase activity
Published online: 26-Jan-2024
Year: 2024, Volume: 125, Issue: 4 Page From: 233, Page To: 238
doi:10.4149/BLL_2024_35


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