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Bratislava Medical Journal Ahead of print Bratislava Medical Journal Vol.125, No.6, p.382–386, 2024
Bratislava Medical Journal Ahead of print Bratislava Medical Journal Vol.125, No.6, p.382–386, 2024
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Bratislava Medical Journal Vol.125, No.6, p.382–386, 2024 |
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| Title: Is increased activator protein 1 in cerebrospinal fluid as a potential biomarker that distinguishes idiopathic intracranial hypertension from multiple sclerosis? | ||
| Author: Seyda KARABORK, Humeyra CELIK, Ali Dogan DURSUN, Handan ANKARALI, Sule Aydin TURKOGLU | ||
| Abstract: OBJECTIVES: To distinguish whether idiopathic intracranial hypertension (IIH) is a condition predisposing to multiple sclerosis (MS) or an isolated disease, the current gene transcription factor Activator Protein-1 (AP-1) was evaluated with its potential to differentiate both diseases. BACKGROUND: The aim of this study was to investigate the use of AP-1 as biomarkers for the discrimination of IIH and MS. METHODS: AP-1, TNF-α, and IL-6 protein values in the CSF of the cases were evaluated by the ELISA method. The numerical measures of the groups and the ability of AP-1 to distinguish the groups were analyzed with the ROC curve. RESULTS: There was no difference between the groups in CSF TNF-α, IL-6, CSF, and serum biochemistry analyses. However, it was determined that the AP-1 concentration (pg/ml) was significantly higher in the IIH group, the sensitivity of AP-1 in separating those with IIH was 75%, and the specificity in separating those with MS was 60% in those with an AP-1 concentration of 606.5 and above. CONCLUSION: According to our results, the fact that CSF TNF-α and IL-6 values did not differ in IIH compared to MS revealed that IIH could not methodologically control MS, and AP-1 was a supportive parameter in differentiating both diseases (Tab. 2, Fig. 1, Ref. 31). |
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| Keywords: multiple sclerosis, idiopatic intracranial hypertension, activator protein-1, cerebrospinal fluid, inflammation | ||
| Published online: 12-Mar-2024 | ||
| Year: 2024, Volume: 125, Issue: 6 | Page From: 382, Page To: 386 | |
| doi:10.4149/BLL_2024_58 |
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