Neoplasma Vol.71, No.2, p. 117–122, 2024
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| Title: Participation of suicide gene extracellular vesicles in metastasis prevention |
| Author: Dajana Vanova, Michal Andrezal, Jana Jakubechova, Ursula Altanerova, Cestmir Altaner |
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Abstract: The incidence of distant metastases is associated with most cancer-related mortalities. Extracellular vesicles (EVs), secreted from tumors and cancer-associated fibroblasts, are involved in the metastatic process mediating their organotropism through their involvement in the pre-metastatic niche formation. We have been developing suicide gene therapy mediated by EVs secreted from mesenchymal stem/ stromal cells, tumor cells, and cancer-associated fibroblasts. Suicide gene EVs conjugated with prodrug are tumor tropic, penetrate tumor cells, and kill them by intracellular conversion of nontoxic prodrug to an efficient anti-cancer drug. Here, we discuss findings regarding the possibility of using suicide gene EVs as a novel therapeutic approach for metastases, via pre-metastatic niche modification. The suicide gene EVs provide a future perspective for metastasis prevention.
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| Keywords: tumor-derived EVs; pre-metastatic niche; metastatic organotropism; suicide gene tumor-derived EVs; metastasis prevention |
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Published online: 20-May-2024
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| Year: 2024, Volume: 71, Issue: 2 |
Page From: 117, Page To: 122 |
doi:10.4149/neo_2024_240208N59
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