Bratislava Medical Journal Vol.125, No.7, p.435

Bratislava Medical Journal Vol.125, No.7, p.435–440, 2024

Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

Impact factor 1.5

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Bratislava Medical Journal Vol.125, No.7, p.435–440, 2024
Title: Modeling brain pathology to study nose-to-brain drug delivery
Author: Аltynay TALGATKYZY, Talgat KHAIBULLIN, Marat SYZDYKBAYEV, Maksut KAZYMOV, Alua SHARAPIYEVA, Kuralay AMRENOVA, Shagiyeva DINARA, Вakytkul ТOKTABAYEVA, Meruyert KHAMITOVA, Bakytbek APSALIKOV, Elvira OZHMUKHAMETOVA

Abstract: OBJECTIVES: To create a new mucoadhesive dosage form based on PluronicF127 followed by transformation into a gel form upon intranasal administration for targeted delivery to brain tissue METHODS: Citicoline, cytidine diphosphocholine, designated as CDP-choline, was purchased as a white powder with the molecular weight of 510.31 g/mol. The triblock copolymers of polyethylene glycol-block-polypropylene glycol-block-polyethylene glycol (PEG-PPG-PEG), branded as Pluronic F127, was used. RESULTS: When instilled into the nasal cavity, Pluronic F127 for intranasal administration is transformed into a gel that remains retained for 45-55 minutes, which promotes better penetration of drugs into the brain tissue. CONCLUSION: The polymer’s gelling and adhesive properties performed well, which is crucial for further research at the preclinical stage (Tab. 1, Fig. 5, Ref. 28).

Keywords: pluronic F127, intranasal solution, cytidine diphosphocholine
	Published online: 21-May-2024
Year: 2024, Volume: 125, Issue: 7	Page From: 435, Page To: 7440
doi:10.4149/BLL_2024_67
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