Home General Physiology and Biophysics 2024 General Physiology and Biophysics Vol.43, No.4, p. 335–346, 2024

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Founded: 1982
ISSN 1338-4325 (online)
ISSN 0231-5882 (print)
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General Physiology and Biophysics Vol.43, No.4, p. 335–346, 2024

Title: A2A adenosine receptor stimulation ameliorated diabetic-induced osteoporosis in rats
Author: Manal S. Abd-El Hamid, Ebtessam A. Abou-Shady, Nourhan A. Mohamed, Wessam E. Morsy
Abstract: Diabetic osteoporosis is a common health problem that is associated with a disruption in bone metabolism. A2A adenosine receptor (A2AAR) signaling seems to play a critical role in bone homeostasis. This study aimed to evaluate the effect of A2AAR stimulation on the treatment of diabetic-induced osteoporosis versus insulin treatment. Forty adult male rats were allocated into control (C), untreated diabetic-induced osteoporosis (DIO), insulin-treated DIO (I-DIO), and A2AAR agonist-treated DIO (A-DIO) groups. Both insulin and A2AAR agonist treatments significantly increased serum insulin level, glutathione peroxidase (GPx) activity, bone expression of osteoprotegerin (Opg) and β-catenin (Ctnnb1), and cortical and trabecular bone thickness, whereas they decreased serum fasting glucose, malondialdehyde (MDA), tumor necrosis factor α (TNF-α), bone expression of receptor activator of nuclear factor kappa-B ligand (Rankl), runt-related transcription factor-2 (Runx2), and sclerostin (Sost) versus the untreated DIO groups. A2AAR agonist treatment was more effective than insulin in ameliorating diabetic osteoporosis. This might be attributed to the upregulation of β-catenin gene expression, enhancing its anabolic effect on bone, in addition to the A2AAR agonist’s anti-oxidative, anti-inflammatory, and anti-diabetic effects.

Keywords: A2A adenosine receptor — β-catenin — Diabetes — Osteoporosis
Published online: 29-Jun-2024
Year: 2024, Volume: 43, Issue: 4 Page From: 335, Page To: 346
doi:10.4149/gpb_2024018


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