Home General Physiology and Biophysics 2024 General Physiology and Biophysics Vol.43, No.4, p. 367–370, 2024

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Founded: 1982
ISSN 1338-4325 (online)
ISSN 0231-5882 (print)
Published in English,
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General Physiology and Biophysics Vol.43, No.4, p. 367–370, 2024

Title: CHORDC1, the novel interacting partner of tau protein
Author: Karoline Pichlerová, Jakub Šinský, Matej Kotásek, Petra Majerová, Jozef Hanes
Abstract: Alzheimer’s disease is currently not curable. Almost all attempts to identify disease-modifying drugs failed and the causes of disease etiology are not well understood. Neurofibrillary tangles composed of pathological tau protein belong to the main hallmarks of this disease. Identification of novel physiological and pathological tau interacting proteins may lead to a better understanding of Alzheimer’s disease pathology and tau physiology and therefore we performed a screening of the brain library by a yeast two-hybrid system intending to identify new tau interaction partners. We identified CHORDC1 (cysteine and histidine-rich domain-containing protein 1) as a novel tau interaction partner by this approach. The CHORDC1-tau interaction was validated by co-immunoprecipitation from rat brain tissues and by in vitro co-localization in the cellular model expressing full-length human tau protein. We believe that our results can be useful for researchers studying tau protein in health and disease.
Keywords: Protein-protein interactions — Tau protein — Alzheimer’s disease — Yeast two-hybrid system
Published online: 29-Jun-2024
Year: 2024, Volume: 43, Issue: 4 Page From: 367, Page To: 370
doi:10.4149/gpb_2024019


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