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General Physiology and Biophysics 2024 General Physiology and Biophysics Vol.43, No.5, p, 457–467, 2024
General Physiology and Biophysics 2024 General Physiology and Biophysics Vol.43, No.5, p, 457–467, 2024
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General Physiology and Biophysics Vol.43, No.5, p, 457–467, 2024 |
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| Title: Peripheral nesfatin-1 reduces basal brain activity but has limited effect on epilepsy-like conditions | ||
| Author: Ömer Faruk Kalkan, Osman Aktaş, Zafer Şahin, Selcen Aydin Abidin, Abdulhamit Yildirim, Ali Faruk Özyaşar, İbrahim Uzunand İsmail Abidin | ||
| Abstract: In this study, we investigated the effects of peripheral nesfatin-1 on basal brain activity and 4-aminopyridine (4-AP)-induced epileptiform activity, and its relationship with the electrocorticogram (ECoG) power spectrum and EEG bands. Forty-nine male Wistar rats were divided into seven groups: control sham, 4-AP (2.5 mg/kg i.p.), Nesfatin-1 (1, 2, and 4 µg/kg i.p.), Nesfatin-1 (2 µg/kg) post-treatment, and Nesfatin-1 (2 µg/kg) pre-treatment. Recordings were conducted for 70 min under ketamine/xylazine (90/10 mg/kg) anesthesia. In the post-treatment group, nesfatin-1 was injected 20 min after 4-AP induction. In the pre-treatment groups, nesfatin-1 was administered following basal recordings and before 4-AP injection. 4-AP induced epileptiform activity in all animals, peaking at 30 min. Nesfatin-1 (2 µg/kg) reduced basal brain activity (p 0.05) but increased gamma band activity (p > 0.05). Pre-treatment of nesfatin-1 reduced epileptiform activity between 50 and 60 min (p 0.05). We conclude that peripheral nesfatin-1 modulates normal brain activity but has limited effects on abnormal discharges. |
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| Keywords: Nesfatin-1 — Neuropeptide — Epilepsy — EEG — 4-Aminopyridine | ||
| Published online: 16-Aug-2024 | ||
| Year: 2024, Volume: 43, Issue: 5 | Page From: 457, Page To: 467 | |
| doi:10.4149/gpb_2024026 |
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