Bratislava Medical Journal Vol.125, No.10, p.587

Bratislava Medical Journal Vol.125, No.10, p.587–588, 2024

Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

Impact factor 1.5

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Bratislava Medical Journal Vol.125, No.10, p.587–588, 2024
Title: Porphyria cutanea tarda triggered by hepatitis-E virus
Author: Pavel HRABAK, Katerina BENESOVA, Daniela ZAHORAKOVA, Radan BRUHA

Abstract: Porphyria cutanea tarda (PCT) is the most common chronic porphyria, with approximate prevalence of 1:10,000. PCT is frequently associated with hepatitis C virus (HCV), malignant lymphoma and iron overload. Here, we present a case of PCT onset subsequent to hepatitis E virus infection (HEV), characterised by symptoms including skin fragility, haemorrhagic bullous skin exanthema, and onycholysis. The patient was successfully treated by erythrocytapheresis and hydroxychloroquine. After exclusion of other possible causes of PCT, HEV infection was identified as the likely trigger of the disease in this genetically predisposed individual, representing the first reported instance of such an association. Erythrocytapheresis emerged as a viable alternative to phlebotomy for PCT treatment. This case underscores the significance of considering HEV infection in the aetiology of PCT and highlights erythrocytapheresis as a promising therapeutic approach (Ref. 8). Text in PDF www.elis.sk

Keywords: hepatitis E, porphyria cutanea tarda, erythrocytapheresis, hydroxychloroquine
	Published online: 26-Aug-2024
Year: 2024, Volume: 125, Issue: 10	Page From: 587, Page To: 588
doi:10.4149/BLL_2024_91
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