Home Bratislava Medical Journal 2024 Bratislava Medical Journal Vol.125, No.10, p.648–651, 2024

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

Impact factor 1.5

 

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Bratislava Medical Journal Vol.125, No.10, p.648–651, 2024

Title: A genome-wide association study of longitudinal change in CSF tau among non-demented elderly
Author: Yingbei LIU, Na ZHANG, Shulei LIU, Xiaoling ZHONG, Ling WANG
Abstract: METHODS: This study conducted a genome-wide association study (GWAS) on longitudinal CSF t-tau and genotype data from 319 non-Hispanic Caucasians within the Alzheimer’s Disease Neuroimaging Initiative (ADNI) cohort. The aim was to identify genetic determinants influencing the rate of change in CSF t-tau, a key biomarker in AD.
RESULTS: The GWAS identified a significant single nucleotide polymorphism (SNP), rs17149074, within the C9orf171 (CFAP77) gene region that showed significant association with changes in CSF t-tau over time. Additionally, five other SNPs–rs10916844, rs10916846, rs9425869, rs3744474, and rs8078303–were found to potentially influence CSF t-tau variability.
CONCLUSIONS: These findings not only enhance our understanding of t-tau’s progression in AD but also suggest that these identified SNPs could serve as novel genetic biomarkers, potentially providing novel insights in the prognostic landscape of AD by refining the predictive value of CSF-tau measurements (Tab. 2, Fig. 2, Ref. 31). Text in PDF www.elis.sk
Keywords: cerebrospinal fluid, t-tau, genome-wide association study, single nucleotide polymorphism, genetic factors
Published online: 26-Aug-2024
Year: 2024, Volume: 125, Issue: 10 Page From: 648, Page To: 651
doi:10.4149/BLL_2024_99


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