Home Bratislava Medical Journal 2024 Bratislava Medical Journal Vol.125, No.10, p.652–656, 2024

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

Impact factor 1.564

 

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Bratislava Medical Journal Vol.125, No.10, p.652–656, 2024

Title: The ratio of brain natriuretic peptide level and computed tomography pulmonary angiography parameters in pulmonary embolism in relation to sex
Author: Jelena BOSKOVIC SEKULIC, Igor SEKULIC, Boris DZUDOVIC, Bojana SUBOTIC, Ljiljana JOVANOVIC, Sonja SALINGER, Jovan MATIJASEVIC, Tamara KOVACEVIC, Irena MITEVSKA, Vladimir MILORADOVIC, Aleksandar NESKOVIC, Slobodan OBRADOVIC

Abstract: OBJECTIVES: The objective of this study was to investigate whether there are differences between brain natriuretic peptide (BNP) levels and computed tomography pulmonary angiography (CTPA) parameters, in patients with acute PE, with respect of sex.
BACKGROUND: Acute pulmonary embolism (PE) may provoke sudden right ventricle overload and stretching of their thin walls, causing significant raise of BNP blood levels, which correlates to acute PE severity. The properties of RV are different between sexes.
METHODS: This retrospective analysis was gained from the data of 1612 PE patients from the regional PE register. The patients have had CTPA verification of PE, with described localization of thrombus masses, as well as the ratio between RV and left ventricle (RV/LV), and BNP as biomarker, measured during the first 24 hours upon admission.
RESULTS: Out of 96 male patients with detected central thrombus, 75.0% patients had an increase in BNP level compared to 25.0% patients with normal BNP value (p<0.001). Of the 94 female patients with central thrombus, 85.1% patients had an elevated BNP level, compared to 14.9% patients, with BNP normal values (p<0.001). Of the 135 male patients with RV/LV˃1, 79.3% of them, had elevated BNP, compared to 20.7% patients whose BNP level was normal (p<0.001). Out of 123 female patients with RV/LV˃1, 91.1% patients had elevated BNP compared to 8.9%, whose BNP was normal (p<0.001).
CONCLUSION: Elevated BNP blood level correlates with CTPA parameters, such as the presence of central thrombus and the ratio between right and left ventricles greater than 1, in patients with acute PE, regardless of sex (Tab. 2, Fig. 2, Ref. 23). Text in PDF www.elis.sk

Keywords: acute pulmonary embolism, computed tomography pulmonary angiography, brain natriuretic peptide, right ventricle.
Published online: 26-Aug-2024
Year: 2024, Volume: 125, Issue: 10 Page From: 652, Page To: 656
doi:10.4149/BLL_2024_100


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