Home Bratislava Medical Journal 2024 Bratislava Medical Journal Vol.125, No.11, p 724–727, 2024

Journal info


 


Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

Impact factor 1.5

 

Select Journal







Webshop Cart

Your Cart is currently empty.
Info: Your browser does not accept cookies. To put products into your cart and purchase them you need to enable cookies.

Bratislava Medical Journal Vol.125, No.11, p 724–727, 2024

Title: MMP9 and pancreatic cancer
Author: Veronika ROSKOVICOVA, Jana KATUCHOVA, Ivana VECURKOVSKA, Jana MASLANKOVA, Maria MAREKOVA, Jozef RADONAK, Vladimir KATUCH
Abstract: BACKGROUND: Pancreatic carcinoma is one of the most severe oncological diseases of the gastrointestinal tract. At the time of diagnosis, up to 28% of patients have metastatic liver damage, and only 5% of patients survive five years. Scientific research focuses on non-invasive markers that could help screen for the disease and identify patients more quickly. Potential biomarkers also include matrix metalloproteinases, which play a role in oncogenesis.
MATERIAL AND METHODS: We prospectively followed 46 patients with pancreatic cancer and benign pancreatic diseases from September 2022 to March 2023. We determined the level of MMP9 in serum and tissue biopsied during surgeries.
RESULT: As a result, MMP9 levels were elevated from the T2 stage. The correlation between disease stage and MMP9 level was not confirmed in lower stages, possibly due to the small group of patients.
CONCLUSION: MMP9 seems suitable for detecting late stages of pancreatic cancer, possibly for secondary prevention. We could not confirm a correlation between MMP9 levels and the initial stages of the disease (Tab. 1, Fig. 3, Ref. 21). Text in PDF www.elis.sk
Keywords: pancreatic cancer, MMP9, marker, non-invasive, screening
Published online: 01-Nov-2024
Year: 2024, Volume: 125, Issue: 11 Page From: 724, Page To: 727
doi:10.4149/BLL_2024_110


download file


© AEPress s.r.o
Copyright notice: For any permission to reproduce, archive or otherwise use the documents in the ELiS, please contact AEP.