Home Bratislava Medical Journal 2024 Bratislava Medical Journal Vol.125, No.11, p 728–733, 2024

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

Impact factor 1.5

 

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Bratislava Medical Journal Vol.125, No.11, p 728–733, 2024

Title: Efficiency of photodynamic inactivation Actinomyces israelii and Prevotella melaninogenica
Author: Iryna VORONKINA, Adriana LIPTAKOVA, Valentina DYACHENKO, Svetlana DERKACH, Nadejda SKLYAR
Abstract: BACKGROUND: The goal of our work was to develop a composition for antimicrobial photodynamic inactivation (aPDI) of anaerobic periodontopathogenic pathogens.
METHODS: The three test groups were as follows: light plus doxycycline (L+DOX+), light plus doxycycline and hypericin (L + DOX + HYP +), and control groups. aPDI was evaluated by the number of grown colonies on a dense nutrient medium after 12, 24, and 48 hours of bacterial suspension cultivation.
RESULTS: Based on the results of microbiological studies, the combined photosensitising effect of a subinhibitory dose of doxycycline and hypericin was determined. The delay of growth of A. israelii, P. melaninogenica in the second group (L+DOX+HYP) was significantly significant compared to the first group (L+DOX+), and the statistical difference in colony formation activity was found for both gram-positive and gram-negative cultures (p<0.05).
CONCLUSIONS: aPDT is a promising therapeutic alternative for the local treatment of purulent-inflammatory diseases of various localisation caused by antibiotic-resistant bacteria, including in the oral cavity (Fig. 3, Ref. 57). Text in PDF www.elis.sk
Keywords: peri-implant diseases, photodynamic therapy, photosensitiser, anaerobic bacteria
Published online: 01-Nov-2024
Year: 2024, Volume: 125, Issue: 11 Page From: 728, Page To: 733
doi:10.4149/BLL_2024_112


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