Home General Physiology and Biophysics 2024 General Physiology and Biophysics Vol.43, No.6, p, 535–543, 2024

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Founded: 1982
ISSN 1338-4325 (online)
ISSN 0231-5882 (print)
Published in English,
6 times per year

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General Physiology and Biophysics Vol.43, No.6, p, 535–543, 2024

Title: Neuroprotective effects of coffee-derived exosome-like nanoparticles against Aβ-induced neurotoxicity
Author: Meric A. Esmekaya, Burhan Ertekin
Abstract: The present study aimed to provide experimental evidence that CDELNs (coffee-derived exosome-like nanoparticles) may be a candidate for the treatment or prevention of amyloid-β (Aβ)-induced Alzheimer’s disease (AD). An in vitro Alzheimer’s model was created with Aβ-induced toxicity in mouse hippocampal neuronal cells (HT-22). Aβ(1-42)-exposed cells were treated with different concentrations of CDELNs (1–50 μg/ml) and the viability of cells was analyzed. The change in the mitochondrial membrane potential (ΔΨm) of cells was also determined. CDELNs treatment increased the viability of Aβ(1-42 )-toxicity-induced HT-22 cells significantly. The increase in the viability of Aβ(1-42)-toxicity-induced cells was correlated with an improvement in ΔΨm. CDELNs treatment restored the dissipated ΔΨm. These results suggested that CDELNs protect neuronal cells against Aβ(1-42)-induced neurotoxicity by repairing mitochondrial dysfunction. CDELNs might be a useful neuroprotective agent for the treatment or prevention of Aβ-induced AD. Further animal and clinical studies should be carried out to investigate the neuroprotective potential of CDELNs against Aβ-induced AD.
Keywords: Alzheimer’s disease — Amyloid-β — Coffee-derived exosome-like nanoparticles — HT-22 cell
Published online: 14-Nov-2024
Year: 2024, Volume: 43, Issue: 6 Page From: 535, Page To: 543
doi:10.4149/gpb_2024025


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