General Physiology and Biophysics Vol.44, No.1, p, 73

General Physiology and Biophysics Vol.44, No.1, p, 73–79, 2025

Founded: 1982
ISSN 1338-4325 (online)
ISSN 0231-5882 (print)
Published in English,
6 times per year

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General Physiology and Biophysics Vol.44, No.1, p, 73–79, 2025
Title: Basic pharmacological evaluation of modified phenyl carbamic acid derivatives on cardiovascular functions under in vitro conditions in rats
Author: Eva Kralova, Ivan Malik

Abstract: The study aimed to evaluate the basic pharmacological effects of modified phenyl carbamic acid derivates with a basic part made of N-phenylpiperazine (compounds 6a, 6b, 6c, 6d) in Wistar rats. The compounds were evaluated for their ability to decrease the phenylephrine-induced contraction of the aortic strips of rats after repeated administration of the compounds and their ability to inhibit the positive chronotropic effect of isoproterenol on spontaneously beating rat atria. The ability to inhibit the vasoconstriction effect of phenylephrine was confirmed in all compounds in the range from 10.39 % to 13.65 %. The most significant vasoconstriction was achieved in compound 6d (86.35%, p was identified for the compound 6c (pA2 = 8.21 ± 0.56; p (by 3.17%, p an indicate its potential negative chronotropic effect. The obtained results showed that the evaluated compounds confirmed the basic characteristics of beta-blockers with additional α-adrenolytic properties.

Keywords: Beta-blockers — Phenyl carbamic acid derivates — Isolated aorta — Isolated atrium — Rat

Year: 2025, Volume: 44, Issue: 1	Page From: 73, Page To: 79
doi:10.4149/gpb_2024041
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