Home General Physiology and Biophysics 2025 General Physiology and Biophysics Vol.44, No.3, p, 213–226, 2025

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Founded: 1982
ISSN 1338-4325 (online)
ISSN 0231-5882 (print)
Published in English,
6 times per year

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General Physiology and Biophysics Vol.44, No.3, p, 213–226, 2025

Title: Hsa_circ_0007905 as a modulator of miR-330-5p and VDAC1: Enhancing stemness and reducing apoptosis in cervical cancer stem cells
Author: JianPing Zheng, Yan Feng, ChaoYan Yuan
Abstract:  Circular RNAs (circRNAs) are covalently closed RNA structures that play a pivotal role in the initiation and progression of cervical cancer (CC). However, it is unclear how these RNAs influence cancer stem cell (CSC)-like properties in CC. Here, we performed circRNA microarray analysis and identified an intergenic circRNA, hsa_circ_0007905, that was significantly upregulated in patients with CC. Moreover, hsa_circ_0007905 was found to be highly expressed in CSC-enriched subsets of cervical cancer cell lines. Functionally, knocking down hsa_circ_0007905 suppressed proliferative, migratory invasive and self-renewal abilities, as well as stimulated apoptosis of CSCs in CC. Mechanistically, hsa_circ_0007905 functions as a “sponge” to inversely control miR-330-5p expression, which directly targets VDAC1. Overexpressing VDAC1 or inhibiting miR-330-5p blocked the roles of silencing hsa_circ_0007905 on CSCs. Thus, we revealed the mechanism by which hsa_circ_0007905 competitively adsorbs miR-330-5p to mediate VDAC1 expression to promote stemness and inhibit apoptosis of CSCs in CC, offering an therapeutic target for treating CC.
Keywords: Cervical cancer stem cells — hsa_circ_0007905 — miR-330-5p — VDAC1 — Apoptosis
Year: 2025, Volume: 44, Issue: 3 Page From: 213, Page To: 226
doi:10.4149/gpb_2024049


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