Home 
Neoplasma Ahead of print neo_2026_260529N175
Neoplasma Ahead of print neo_2026_260529N175
Journal info
|
||
Select Journal
Journals
Ekologia - Ecology Endocrine Regulations General Physiology and Biophysics Neoplasma 2026 Ahead of print 2025 2024 2023 2022 2021 2020 2019 2018 2016 2017 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 Studia Psychologica Psychológia a patopsych. dieťaťa Kovove Materialy-Metallic Materials Slovenská hudba 2025Webshop Cart
Your Cart is currently empty.
Info: Your browser does not accept cookies. To put products into your cart and purchase them you need to enable cookies.
neo_2026_260529N175 |
||
| Title: CRISPR/Cas9-edited organoids as a platform for tailored research of colorectal cancer | ||
| Author: Nikoleta Mojzesova, Petra Hladikova, Zuzana Kozovska, Martina Poturnajova, Silvia Tyčiakova, Miroslava Matuskova | ||
| Abstract: Colorectal cancer is one of the most commonly diagnosed cancers worldwide. Mortality rates and limited therapeutic options justify the development of reliable preclinical research models, as their translational value remains limited. Simple in vitro models do not recapitulate tumor heterogeneity, while in vivo research faces ethical concerns and interspecies differences. Patient-derived organoids offer a physiologically more relevant platform that retains the genetic, epigenetic, and phenotypic characteristics of the original tumor. Tumor-derived organoids enable precise investigation of novel treatments, functional genomics, and modeling of cancer development. Integration with CRISPR/Cas9 gene editing further enables accurate manipulation of specific genes to study carcinogenesis and therapeutic resistance. This review highlights recent advances in the use of organoids for colorectal cancer research and explores the potential of gene-edited organoids to discover the genetic and molecular mechanisms underlying colorectal cancer development, progression, and treatment resistance. |
||
| Keywords: colorectal cancer; patient-derived organoids; CRISPR/Cas9; gene editing | ||
| Year: , Volume: , Issue: | Page From: , Page To: | |
| doi:10.4149/neo_2026_260529N175 |
||
|
|
 download file |
|