Home Neoplasma Ahead of print neo_2026_260310N61

Journal info


6 times a year.
Founded: 1954
ISSN 0028-2685
ISSN 1338-4317 (online)

Published in English

Editorial Info
Abstracted and Indexed
Submission Guidelines

Select Journal







Webshop Cart

Your Cart is currently empty.
Info: Your browser does not accept cookies. To put products into your cart and purchase them you need to enable cookies.

neo_2026_260310N61

Title: Transcriptomic analysis of vitamin D3 (cholecalciferol)-mediated attenuation of cisplatin sensitivity in gastric cancer cells in vitro
Author: Ke Chen, Yu Pan
Abstract: Cisplatin remains a cornerstone of chemotherapy for gastric cancer, but acquired resistance frequently limits its therapeutic efficacy. Vitamin D3/cholecalciferol (VD3) is widely used as a nutritional supplement; however, its influence on cisplatin responsiveness in gastric cancer cells remains unclear. In this study, gastric cancer cell lines were treated with cisplatin in the presence or absence of VD3, and cell viability, apoptosis, reactive oxygen species (ROS) accumulation, DNA damage-associated signaling, and transcriptomic changes were evaluated. VD3 significantly attenuated cisplatin-induced cytotoxicity in AGS, HGC-27, and MKN-45 cells. Co-treatment with VD3 reduced cisplatin-induced apoptosis, ROS accumulation, PARP cleavage, and γH2AX activation. Transcriptomic analysis showed that VD3 markedly reduced the number of cisplatin-responsive differentially expressed genes and altered gene programs associated with extracellular matrix organization, steroid metabolism, DNA damage response, and ABC transporter-related pathways. These findings suggest that VD3 exposure can attenuate cisplatin-induced cellular responses in gastric cancer cells and modulate transcriptional programs associated with cisplatin treatment. Given that the study was performed under in vitro conditions, further investigations are required to determine the underlying mechanisms and the potential clinical relevance of these observations.
Keywords: gastric cancer; cholecalciferol; cisplatin resistance; transcriptome sequencing; apoptosis
Year: , Volume: , Issue: Page From: , Page To:
doi:10.4149/neo_2026_260310N61


download file


© AEPress s.r.o
Copyright notice: For any permission to reproduce, archive or otherwise use the documents in the ELiS, please contact AEP.