Home Neoplasma 2007 Neoplasma Vol.54, p.304-310, 2007

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Founded: 1954
ISSN 0028-2685
ISSN 1338-4317 (online)

Published in English

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Neoplasma Vol.54, p.304-310, 2007

Title: A study on notch signaling in human breast cancer
Author: S. ZANG, CH. JI, XUN QU, X. DONG, D. MA, J. YE, R. MA, J. DAI, D. GUO

Abstract: Breast cancer is one of the leading causes of cancer death in women. The Notch family of proteins plays crucial roles in determining cell fates such as proliferation, differentiation and apoptosis. A role for Notch signaling in human breast cancer has been suggested by the development of adenocarcinomas in the murine mammary gland. However, it is not clear currently whether Notch signaling is frequently expressed and activated in breast cancers. Here we show that Notch signaling is overexpressed and highly activated in breast cancers. More significantly, the attenuation of Notch signaling by γ-secretase inhibitor can inhibit the proliferation of breast cancer cells by both causing cell cycle arrest and apoptosis. Thus, targeting Notch signaling may be of therapeutic value in breast cancers.

Keywords: Human breast cancer; Notch; γ-secretase inhibitor; Cell cycle; Apoptosis
Year: 2007, Volume: 54, Issue: Page From: 304, Page To: 310

Price: 16.80 €






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