Neoplasma Vol.54, p.484-489, 2007
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Title: Association of interleukin-8 (IL-8 or CXCL8) -251T/A
and CXCR2 +1208C/T gene polymorphisms with breast cancer |
Author: E. KAMALI-SARVESTANI, M.R. ALIPARASTI, S. ATEFI |
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Abstract: A case-control study involving 257 breast cancer patients with invasive ductal carcinoma and 233 healthy women
was carried out to explore if the IL-8 -251T/A polymorphism and the CXCR2 +1208 C/T polymorphism have a role in
breast cancer susceptibility. Genotypic analysis showed an increased frequency of high producer IL-8 -251AA genotype
(p=0.016) in the patient group as compared to controls while CXCR2 +1208 C/T polymorphism did not show any
differences between studied groups. However, in contrast to IL-8 -251 polymorphism, the percentage of CXCR2 +1208
TT genotype was significantly lower in patients with NPI≤3.4 compared to NPI>3.4 (2% and 12%, respectively;
p=0.03). Also, ER- tumors showed an approximately significant higher CXCR2 +1208 TT genotype compared to ER+
tumors (18.6% and 7.1%, respectively; p=0.07). In conclusion, IL-8 -251T/A polymorphism is associated with
development of invasive ductal carcinoma type of breast cancer while CXCR2 +1208C/T polymorphism may affect
the disease progression.
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Keywords: Breast Cancer; IL-8; CXCR2; Polymorphism. |
Year: 2007, Volume: 54, Issue: |
Page From: 484, Page To: 489 |
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