Home Neoplasma 2008 Neoplasma Vol.55, No.5, p.400-408, 2008

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Founded: 1954
ISSN 0028-2685
ISSN 1338-4317 (online)

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Neoplasma Vol.55, No.5, p.400-408, 2008

Title: Combined molecular biological and molecular cytogenetic analysis of genomic changes in 146 patients with B-cell chronic lymphocytic leukemia
Author: A. BERKOVA, L. PAVLISTOVA, L. BABICKA, L. HOUSKOVA, J. TAJTLOVA, P. BALAZI, E. CMUNT, J. SCHWARZ, J. KARBAN, M. TRNENY, J. BREZINOVA, Z. ZEMANOVA, K. MICHALOVA

Abstract: Interphase fluorescence in situ hybridization was used to detect common deletions in B-CLL patients as well as trisomy 12 and aberrations of IgH gene complex at 14q32.33 where we evaluated not only translocation-like signal pattern but also deletions. 120 (82%) patients showed genetic changes – del(13)(q14) 95 (62%), deletion of ATM gene 22 (15%), deletion of p53 gene 25 (17%) and trisomy 12 was proved in 18 (12%) cases. IgH rearrangements were detected in 45 (31%), split of the signals in 11 (8%), deletion of 3´segment flanking IgH gene in 5 (3%) and deletions of variable segment in 29 (20%) patients. Although deletions of 3´segment flanking IgH gene complex are supposed to have an adverse prognostic impact and the genetic background of variable segment deletions is believed to be most probably physiological, we assumed a detailed mapping of the 14q32.33 region will be needed to unravel these mysteries.

Keywords: B-CLL; I-FISH; IgH gene complex deletions; prognosis
Year: 2008, Volume: 55, Issue: 5 Page From: 400, Page To: 408

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