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Acta Virologica Vol.49, p.207-210, 2005 |
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Title: DEVELOPMENT OF RABIES DNA VACCINE USING A RECOMBINANT PLASMID | ||
Author: N. RAI, P. KAUSHIK, A. RAI | ||
Abstract: A recombinant plasmid pTargeT.rabgp containing the glycoprotein (G) gene of Rabies virus
(RV) was constructed and produced for immunogenicity studies on mice and dogs. The mice immunized twice
with 50 μg or 100 μg of pTargeT.rabgp intramuscularly (i.m.), showed a serum antibody titer of 256 or 64,
respectively 14 days post immunization (p.i.). When the vaccinated mice were challenged at 14 days p.i. with
RV i.c., they were protected in 81.25% or 87.5%, respectively. A positive cell mediated immune response was
observed by lymphocyte proliferation assay and macrophage migration inhibition test. These results indicate
that the pTargeT.rabgp plasmid can be used as a rabies DNA vaccine. |
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Keywords: Rabies virus; DNA vaccine; glycoprotein gene; protection; neutralization test; antibody titer | ||
Year: 2005, Volume: 49, Issue: | Page From: 207, Page To: 210 | |
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