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Acta Virologica Vol.51, p.101-108, 2007 |
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Title: INFLUENZA A VIRUS PB1-F2 PROTEIN | ||
Author: H. GOCNIKOVA, G. RUSS | ||
Abstract: PB1-F2 protein (PB1-F2) is encoded by the alternative (+1) ORF in the PB1 gene of influenza A viruses (IAVs). This protein has a number of unique features, namely its absence from some animal IAV isolates, variable expression in individual infected cells, rapid proteasome-dependent degradation, mitochondrial localization, and apoptotic or pro-apoptotic properties. Localization of PB1-F2 to mitochondria is mediated via C-terminal basic amphipathic α-helix. PB1-F2 affects apoptosis and may contribute to the pathogenicity and lethality of IAVs. Sequence analysis showed that, in addition to the strains with an ORF for full-length PB1-F2, there are some with an ORF for different truncated forms of PB1-F2. Several other viruses encode proteins with structure and function similar to PB1-F2 of IAVs. |
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Keywords: Influenza A virus; PB1-F2; ORF; mitochondrial membrane amphipathic α-helix; apoptosis; truncation | ||
Year: 2007, Volume: 51, Issue: | Page From: 101, Page To: 108 | |
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