Home HOME General Physiology and Biophysics 2010 General Physiology and Biophysics Vol.29, No.4, p.355-361, 2010

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Quarterly, 80 pp. per issue
Founded: 1982
ISSN  1338-4325 (online)

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General Physiology and Biophysics Vol.29, No.4, p.355-361, 2010

Title: Interaction of long-chain n-alcohols with fluid DOPC bilayers: a neutron diffraction study
Author: Viktor I. Petrenko, Maria Klacsova, Anatoly I. Beskrovnyy, Daniela Uhrikova, Pavol Balgavy
Abstract:  Lamellar phases composed of fluid dioleoylphosphatidylcholine (DOPC) bilayers containing alkan-1-ols (CnOH, n = 8, 10, 14, 16, 18 is the number of carbon atoms) at CnOH : DOPC = 0.3 molar ratio and hydrated with heavy water at 20.2 ≥ D2O : DOPC ≥ 14.4 molar ratio were studied by neutron diffraction. The bilayer thickness dL and the bilayer surface area AL per DOPC at the bilayer-water interface were obtained from the lamellar repeat period d using molecular volumes of DOPC, CnOH and D2O, and the Luzatti’s method. Both the dL and AL increase with the CnOH chain length n at CnOH : DOPC = 0.3 molar ratio: dL = (3.888 ± 0.066) + (0.016 ± 0.005)·n (in nm), AL = (0.6711 ± 0.0107) + (0.0012 ± 0.0008)·n (in nm2).
Keywords: Lipid bilayer — Dioleoylphosphatidylcholine — Alkan-1-ol — Neutron diffraction
Year: 2010, Volume: 29, Issue: 4 Page From: 355, Page To: 361
doi:10.4149/gpb_2010_04_355


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