Home Endocrine Regulations 2005 Endocrine Regulations Vol.39, p.12-20, 2005

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Quarterly, 50 pp. per issue 
Founded: 1967
ISSN 1210-0668
E-ISSN 1336-0329

Published in English

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Endocrine Regulations Vol.39, p.12-20, 2005

Title: HUMAN THYROID IN THE POPULATION EXPOSED TO HIGH ENVIRONMENTAL POLLUTION BY ORGANOCHLORINATED POLLUTANTS FOR SEVERAL DECADES
Author: P. LANGER, A. KOCAN, M. TAJTAKOVA, J. PETRIK, J,. CHOVANCOVA, B. DROBNA, S. JURSA, M. PAVUK, T. TRNOVEC, E. ŠEBÖKOVÁ, I. KLIMEŠ

Abstract: Objective. To study possible effects of long-time exposure of chemical factory employees and population of surrounding polluted area to polychlorinated biphenyls and pesticides on the thyroid volume and function as compared to the population from the area of background pollution. Methods. A total of 461 adults consisting of 239 men and 222 women was examined and divided into four groups according to their permanent domicile as related to the level of environmental pollution, e.g. SR (area of background pollution, n=207), SI (slightly polluted area, n=59), MI (polluted city of Michalovce, n=94) and CH (employees of chemical factory subjected to high PCB exposure, n=101), combined first three groups being also called LPA (less polluted areas, n=360). Thyroid volume (ThV) and echogenicity were measured by real time sonography. The level of polychlorinated biphenyls (PCB) and pesticides (hexachlorbenzene – HCB, DDE (2,2’-2- bis(4-chlorobiphenyl)-1,1-dichloroethylene), p,p’-DDT (2,2’-bis(4-chlorophenyl)-1,1,1-trichloroethane) and ?-, ?- and ?-hexachlorcyclohexane – HCH) was estimated by congener specific analysis using HP 5890 gas chromatograph with a 63Ni electron capture detector. Serum levels of thyrotropin (TSH) and thyroid peroxidase antibodies (anti-TPO) were measured by specific sensitive immunoassays. Results. The association of very high PCB level (e.g. 7300±871 ng/g lipid; mean±S.E.) with increased ThV (e.g. 16.3±0.73 ml) in CH has been found, the values being significantly higher than these of 360 subjects in LPA (e.g. 2045±147 ng/g, p

Keywords: Polychlorinated biphenyls – Pesticides – Industrial pollution – PCB congeners – Hexachlorobenzene – DDE - Thyroid volume - Thyroid disorders
Year: 2005, Volume: 39, Issue: 1 Page From: 12, Page To: 20



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