Home FOR AUTHORS Endocrine Regulations 2006 Endocrine Regulations Vol.40, p.125-128, 2006

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Quarterly, 50 pp. per issue 
Founded: 1967
ISSN 1210-0668
E-ISSN 1336-0329

Published in English

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Endocrine Regulations Vol.40, p.125-128, 2006

Title: EXOGENOUS IL-1β INDUCES ITS OWN EXPRESSION, BUT NOT THAT OF IL-6 IN THE HYPOTHALAMUS AND ACTIVATES HPA AXIS AND PROLACTIN RELEASE
Author: MARTINA SKURLOVA, ANDREA STOFKOVA, JANA JURCOVICOVA

Abstract: Objective: Proinflammatory cytokines IL-1ß, and IL-6 are synthesized in the brain, where they exert local regulatory functions. Our aim was to find out whether, along with the activation of hypothalamo-pituitary-adrenocortical (HPA) axis and prolactin (PRL), the acute systemic enhancement of IL-1ß affects its own production in the hypothalamus as well as that of IL-6. Method: Forty five minutes after a single i.p. administration of recombinant rat IL-1ß (5 μg/kg) to male Long Evans rats we estimated the expression of IL-1ß and IL-6 mRNA in the hypothalamus by real time PCR, ACTH, corticosterone (CORT), and PRL by RIA Results: IL-1ß administration stimulated the expression of IL-1ß mRNA in the hypothalamus by 99 %, but not that of IL-6. It also significantly activated plasma levels of ACTH, PRL, CORT, and CORT production in adrenal gland. Conclusion: These results indicate that acute peripheral enhancement of IL-1ß may induce neuroendocrine changes also via the immediate activation of its own expression in the hypothalamus, but not that of IL-6 expression in the hypothalamus was found.

Keywords: IL-1ß administration – IL-1ß – IL-6 mRNA expression – Hypothalamus – HPA axis – Prolactin
Year: 2006, Volume: 40, Issue: 4 Page From: 125, Page To: 128



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