Home FOR AUTHORS General Physiology and Biophysics 2007 General Physiology and Biophysics Vol.26, p.194-199, 2007

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Founded: 1982
ISSN  1338-4325 (online)

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General Physiology and Biophysics Vol.26, p.194-199, 2007

Title: Natriuretic peptides and endothelin-1 in patients undergoing coronary artery bypass grafting
Author: K. Danova, I. Pechan, I. Olejarova, B. Liska

Abstract: Off-pump coronary artery bypass grafting (CABG) is an alternative to conventional CABG using cardiopulmonary bypass. Off-pump technique reduces the complications of CABG performed with extracorporeal circulatory assistance (Lancey et al. 2000; Mack et al. 2004a,b). The object of this study was to compare peri- and postoperative time courses of vasoactive peptides – atrial natriuretic poptide (ANP), brain natriuretic poptide (BNP) and endothelin-1 (ET-1) in offpump versus on-pump CABG. 22 patients, who underwent on-pump (group A, n = 11) or off-pump CABG (group B, n = 11) were studied. The peri- and postoperative time courses of plasma ANP and BNP were similar in both groups. A statistically significant difference between ET-1 plasma level 2 h after surgery in the group A and ET-1 plasma level 2 h after surgery in the group B (2.46 ± 1.14 pg/ml/Ht versus 0.74 ± 0.09 pg/ml/Ht, p

Keywords: Cardiopulmonary bypass — On-pump CABG — Off-pump CABG — Atrial natriuretic peptide — Brain natriuretic peptide — Endothelin-1
Year: 2007, Volume: 26, Issue: Page From: 194, Page To: 199



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