Neoplasma Vol.52, p.361-363, 2005
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| Title: Expression of the Insulin Receptor Substrate 1 in primary tumors and lymph
node metastases in breast cancer: correlations with Bcl-xL and Bax
proteins
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| Author: M., KODA
; M., SULKOWSKA
; L., KANCZUGA-KODA
; J., GOLASZEWSKA
; W., KISIELEWSKI
; M., BALTAZIAK
; A., WINCEWICZ
; S., SULKOWSKI
; |
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Abstract: In our previous investigation Insulin Receptor Substrate 1 (IRS-1)
correlated with proliferation marker Ki-67 in human
breast cancer. The aim of the present study was to assess
relationships between IRS-1 expression and antiapoptotic Bcl-xL
as well as proapoptotic Bax proteins, assessed by
immunohistochemistry, in primary tumors and lymph node metastases
of breast cancer. IRS-1 is positively associated with both Bcl-xL
and Bax in primary and metastatic tumors. Thus, our results
could suggest that IRS-1 might affect turnover of cancer cells and
breast cancer progression through activation of mitogenesis
and participation in the regulation of the balance between anti-
and proapoptotic pathways.
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| Keywords: insulin receptor substrate 1, Bax, Bcl-xL, breast cancer
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| Year: 2005, Volume: 52, Issue: |
Page From: 361, Page To: 363 |
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