Journal info
|
||
Select Journal
Journals
Bratislava Medical Journal Endocrine Regulations General Physiology and Biophysics Neoplasma 2024 Ahead of print 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 Acta Virologica Studia Psychologica Cardiology Letters Psychológia a patopsych. dieťaťa Kovove Materialy-Metallic Materials Slovenská hudbaWebshop Cart
Your Cart is currently empty.
Info: Your browser does not accept cookies. To put products into your cart and purchase them you need to enable cookies.
Neoplasma Vol.50, p.139-143, 2003 |
||
Title: Correlation of poliferating cell nuclear antigen and bcl-2 expression with tumor front grading and metastasis in laryngeal squamous cell carcinoma | ||
Author: C., BORAN ; L., YILDIZ ; B., KANDEMIR ; F., KARAGOZ ; S., BARIS ; O., AYDIN ; | ||
Abstract: This study was designed to examine the immunohistochemical expression of
proliferating cell nuclear antigen (PCNA) and bcl-2 protein in 45 cases with
advanced laryngeal squamous cell carcinoma who had undergone total laryngectomy
with unilateral modified radical neck dissection, and the relation of this
expression to some prognostic factors such as tumor front grading and neck lymph
node metastases. Sections were reevaluated for routine histologic grade, tumor
front grading and neck lymph node metastases, and were stained with monoclonal
antibodies against PCNA and bcl-2. Significant correlation was present between
the severity of PCNA expression and incidence of lymph node metastasis (p<0.05).
No correlation was found between the severity of PCNA expression and tumor front
grading. Bcl-2 expression did not associate with either parameters. In
conclusion, PCNA is important in predicting prognosis and no association is
present between the bcl-2 protein expression and prognostic factors.
|
||
Keywords: Laryngeal carcinoma, prognosis, tumor front grading, neck lymph node metastases, bcl-2 protein, PCNA. | ||
Year: 2003, Volume: 50, Issue: | Page From: 139, Page To: 143 | |
|
download file |
|