Neoplasma Vol.51, p.465-470, 2004
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Title: Interrelationship between macrophage IL-12, IL-10 and NO secretion
in expression of their tumoricidal activity
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Author: K., KOZLOWSKA
; M., ZARECZNA
; M., CICHOREK
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Abstract: Peritoneal macrophage activity in the secretion of IL-12, IL-10,
NO and interrelationship between these substances in hamster
bearing two lines of transplantable melanomas with different
biological properties were studied.
It has been found that these macrophages lack of homogenous
reactivity in the secretion of studied substances.
Melanotic melanoma line evoked moderate increase secretion of all
above mentioned substances, whereas amelanotic melanoma line,
tumor with higher immunogenicity, tumorogenicity and with shorter
survival time of animals induced considerably increase of IL-12
and NO with prominent decrease of IL-10 secretion. Results allow
to assume that macrophage secretory activity and interrelationship
between these substances is not uniform in two lines of the same
neoplasma and thah it depends on tumor biological properties. Such
observation seems to be useful in case of tumor cytokine
immunotherapy.
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Keywords: macrophages cytotoxicity, transplantable melanoma, IL-12, IL-10, NO
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Year: 2004, Volume: 51, Issue: |
Page From: 465, Page To: 470 |
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