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Neoplasma Vol.53, p.428-433, 2006 |
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Title: Anticancer effects of various Iranian native medicinal plants on human tumor cell lines | ||
Author: Z., AMIRGHOFRAN ; M., BAHMANI ; A., AZADMEHR ; K., JAVIDNIA ; | ||
Abstract: In this study the antineoplastic activity of methanolic extracts
of six medicinal plants that are native to Iran, including
Galium mite, Ferulago angulata, Stachys obtusicrena, Cirsium
bracteosum and Echinophora cinerea was investigated. Different
tumor cell lines were exposed to the extracts and cytotoxic
analysis using MTT colorimetric assay was performed.
Quantification of percentage of cells undergoing apoptotic changes
by flow cytometry, and DNA fragmentation analysis on
sensitive cell lines was then carried out. Results obtained
indicated that almost all of the extracts more or less had the
capacity
to decrease the proliferation of tumor cells. Among the plants,
the highest activity against K562 leukemia cell line was
found for E. cinerea and C. bracteosum with IC50 less than 20
µg/ml followed by G. mite with IC50 of 39.8 µg/ml. F.
angulata and E. cinerea, mostly inhibited Jurkat cells
proliferation (IC50 less than 8 µg/ml). Fifty percent inhibition
of Fen
bladder cell carcinoma due to exposure to F. angulata and E.
cinerea was found at concentrations of nearly 180 µg/ml.
A549, a lung carcinoma cell, was mostly affected by S. obtusicrena
(IC50 more than 200 µg/ml). In flow cytometry analysis,
C. bracteosum, E. cinerea, F. angulata and S. obtusicrena extracts
demonstrated no remarkable effects on the cell cycle profile
of K562 and Jurkat cells. Moreover, in DNA fragmentation analysis
of treated cells, no ladder formation was detected.
In contrary, G. mite caused more than 40% apoptosis in the K562
and Jurkat cells. In DNA fragmentation analysis G. mite
extract produced ladder formation in these cells. In conclusion,
these results indicated that the extracts used in this study
have anti tumor activity particularly against the leukemia cell
lines and that apoptosis is the possible cause of cell death
observed
due to the extract of G. mite.
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Keywords: medicinal plants, cytotoxic activity, apoptosis | ||
Year: 2006, Volume: 53, Issue: | Page From: 428, Page To: 433 | |
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