Neoplasma Vol.52, p.85-94, 2005
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Title: Clinical results of intensity-modulated radiation therapy (IMRT)
for tumors of the head and neck region
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Author: K., ODRAZKA
; J., PETERA
; M., ZOUHAR
; M., VOSMIK
; M., VACULIKOVA
; M., DOLEZEL
; T., KOHLOVA
; S., FILIP
; J., CERAL
; V., HOBZA
; S., REHAK
; J., DOLEZAL
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Abstract: Intensity-modulated radiation therapy (IMRT) is an advanced form
of the three-dimensional conformal radiation therapy (3D-CRT).
Highly conformal dose distribution is the basic feature of IMRT.
The head and neck region is suitable for this new technology since
the primary tumor is often surrounded by several critical
structures. IMRT offers the ability of dose escalation due to
steep dose gradient towards healthy tissues. In this review,
clinical results of IMRT in several head and neck sites are
presented, including intracranial tumors. Parotid-sparing
strategies and patterns of local-regional failures are analyzed.
The possibilities of irradiation of recurrent malignancies are
mentioned. In perspective, the potential of IMRT should be
explored in conjunction with altered fractionation regimens,
including simultaneous integrated boost (SIB). Particularly,
studies with dose escalation are desirable.
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Keywords: IMRT, intracranial tumors, head and neck cancer, patterns of
failure
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Year: 2005, Volume: 52, Issue: |
Page From: 85, Page To: 94 |
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