Neoplasma Vol.53, p.136-143, 2006
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Title: Myelodysplastic syndromes according to FAB and WHO classification. Single center experience
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Author: O., HAUS
; S., KOTLAREK-HAUS
; S., POTOCZEK
; M., CZARNECKA
; E., DUSZENKO
; I., MAKOWSKA
; N., MIROWSKA
; K., KULICZKOWSKI
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Abstract: The results of clinical and laboratory observations of 119 MDS
patients divided acc. to FAB, and – after excluding
RAEB-t and CMML groups – of 95 patients divided acc. to WHO
classification are presented. The diagnosis of MDS was
based on medical interview, physical examination, blood
biochemistry, peripheral blood (PB) and bone marrow (BM)
cytomorphology and cytochemistry, trephine biopsy and cytogenetic
examination. All hematologic examinations were
done according to routine methods. Cytogenetic analyses were
carried out on BM cells from 24–48 h cultures in standard
conditions. At least 15–20 GTG-banded metaphases were analyzed in
every patient.
The survival time (ST) of patients differed significantly between
the FAB or WHO groups, with p=0.0004 for FAB and
p=0.02 for WHO. The progression to AML was more common in less
favorable groups, with p=0.0001 for FAB and
p=0.00016 for WHO. The distribution of IPSS prognostic index among
the groups showed statistically significant difference
(p=0.0004 for FAB, and p=0.0001 for WHO), whereas the distribution
of karyotypic abnormalities did not. However,
in univariate analysis statistically significant influence on ST
showed, beside the both classification systems: cytogenetics,
the presence of blasts in PB, age and IPSS index. In multivariate
analysis the sole independent prognostic factors were: PB
blasts and cytogenetics.
The authors conclude that the WHO classification offers a good
prognostic tool for MDS patients. However, the
karyotype and the presence of blasts in PB should always be taken
into account.
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Keywords: MDS, WHO classification, FAB classification, cytogenetics,
survival time, IPSS
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Year: 2006, Volume: 53, Issue: |
Page From: 136, Page To: 143 |
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