Neoplasma Vol.51, p.385-389, 2004
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Title: Radioguided occult lesion localization (ROLL) of the nonpalpable
breast lesions
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Author: J., ZGAJNAR
; M., HOCEVAR
; S., FRKOVIC-GRAZIO
; K., HERTL
; E., SCHWEIGER
; N., BESIC
; |
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Abstract: Standard localization techniques of the nonpalpable breast lesions
(guide wire, carbon, skin marking) have several disadvantages.
Radioguided occult lesion localization (ROLL) was recently
proposed as a better alternative resulting in wider surgical
margins and lower average specimen weight. The aim of our study
was to compare ROLL to our previously published series of the
standard guidewire localization, performed at the Institute of
Oncology Ljubljana. ROLL was performed in 110 nonpalpable breast
lesions. Human serum albumin macroaggregats, marked with 1.8--5.5
MBq 99mTc was injected in the nonpalpable lesion. During surgery
the radioactive breast tissue was excised using hand held gamma
probe. Nonpalpable breast lesions were excised in all 110
patients. The definitive histology revealed 32 invasive
carcinomas, 19 DCIS, 5 LCIS in and 54 benign breast lesions. Mean
specimen weight was 40 g which is less in comparison to 53 g of
the guidewire series (p=0.002). Surgical margins were clear in
36/51 (70%) invasive breast cancer or DCIS patients and close or
involved in 15/51 (30%) patients. Compared to the guidewire
series, where 41/92 (44%) margins were clear and 51/92 (56%) were
close or involved, the difference was statistically significant
(p=0.005). ROLL proved to be superior to guidewire localization in
our series, allowing excision of the nonpalpable breast lesion
with wider surgical margins despite lower average specimen weight.
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Keywords: radioguided surgery, nonpalpable breast lesions
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Year: 2004, Volume: 51, Issue: |
Page From: 385, Page To: 389 |
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