Neoplasma Vol.57, No.1, p.35-40, 2010
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| Title: Hypermethylation of the GSTP1 promoter region in breast cancer is associated with prognostic clinicopathological parameters |
| Author: Z. LASABOVA, P. TILANDYOVA, K. KAJO, P. ZUBOR, T. BURJANIVOVA, J. DANKO, L. PLANK |
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Abstract: Breast cancer is one of the most common cancer affecting women and the recent research is focused on identifying new genetic and epigenetic prognostic and predictive factors. Glutathione S-transferase P1 (GSTP1) is a biotransformation enzyme expressed in normal breast epithelial cells which can be epigenetically inactivated in breast cancer. We have shown, that application of nested two-stage methylation-specific PCR (MSP) is a suitable method for analysis of epigenetically silenced GSTP1 in formalin-fixed paraffin-embedded (FFPE) tissues from breast cancer patients. Of 45 breast tumors, 11 (24, 4%) were found to have methylated GSTP 1 promoter region. We were able to demonstrate the correlation between the hypermethylation of the GSTP1 promoter region and histological grade of the tumor (p
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| Keywords: breast cancer, prognostic factors, hypermethylation, GSTP1, methylation-specific PCR |
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| Year: 2010, Volume: 57, Issue: 1 |
Page From: 35, Page To: 40 |
doi:10.4149/neo_2010_01_035
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