Home Bratislava Medical Journal 2012 Bratislava Medical Journal Vol.113, No.2, p.80-86, 2012

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

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Bratislava Medical Journal Vol.113, No.2, p.80-86, 2012

Title: Homocysteine Slovakia study: study design and occurrence of hyperhomocysteinaemia and other risk factors
Author: J. Lietava, B. Vohnout B, A. Dukat, G. J. Fodor

Abstract: Background: Slovakia belong to the European Union countries with the high incidence and prevalence of cardiovascular diseases in general and IHD in particular.
Method: Homocystein-Slovakia is crossectional population study realised in subjects in high risk age 35–75 years in two groups. The first consists of patients with verified stable ischemic heart disease (IHD) (M= 152; F = 167) aged 60.8±9.37 yrs (males) res. 63.1±7.56 years (females) (NS) who were randomly selected from two cardiological registrars. Second population was formed by general population who were dichotomised according their medical records into IHD patients (M= 31, F= 53) and apparently healthy controls (M= 47; F = 55), the later in significantly younger age as patients, but in same age for intergender comparison 49.6±10.3 vs 46.6±9.2 yrs (NS).
Results: We found very high prevalence of classic as well as newer risk factors and risk markers both in IHD patients and in controls.
Increased homocysteinen (Hcy >15 µmo/l for males and Hcy >13 µmo/l for females) was found even in 32.9 % of patients and 13.6 % of controls (p<0.001). Comparison of regulating vitamins levels between IHD patients and controls demonstrated similar prevalence.
Conclusion: Homocystein Slovakia study found very high prevalence of hyperhomocysteinemia in patients with stable ischemic heart disease. Even the prevalence in healthy controls correspond to data resported for MI patients in Western countries. Vitamins regulating metabolism of homocysteine also shown high prevalence, however, without differences between IHD pacients and controls (Tab. 5, Fig. 1, Ref. 27).

Keywords: homocystein Slovakia, epidemiology, risk factors, vitamins B6, B12 and folic acid.
Published online: 20-Feb-2012
Year: 2012, Volume: 113, Issue: 2 Page From: 80, Page To: 86
doi:10.4149/BLL_2012_019


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