Home Bratislava Medical Journal 2012 Bratislava Medical Journal Vol.113, No.4, p.214-216, 2012

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

Impact factor 1.564

 

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Bratislava Medical Journal Vol.113, No.4, p.214-216, 2012

Title: Iron-rich complexes in human spleen in hereditary spherocytosis
Author: C. Biro, P. Busikova, G. Fujerikova, O. El-Hassoun, A. Kopaniova, M. Caplovicova, P. Galfiova, V. Sisovsky, M. Kopani , J. Jakubovsky
Abstract: Objective: Tissue iron plays an important role in the development of certain diseases. Although it is one of biogenic elements, its excess induces the reactive oxygen species (ROS) formation. The aim of the present work is to examine the protection against free or loosely bound iron from the view of morphology and chemical composition of iron-rich complexes in human spleen tissues with hereditary spherocytosis (HS) by scanning and transmission electron microscope with energy-dispersive microanalysis (EDX).
Results: The examination of human spleen tissues by scanning and transmission electron microscope showed covering of iron-rich particles. EDX revealed many iron-rich complexes of multi-element composition in HS samples with sulphur and phosphorus as the major elements. Detection was negative in the reference samples.
Conclusion: The covering of iron-rich particles can be explained by elimination and isolation of ferritin/iron complexes from surrounding environment to prevent the ROS formation. Sulphur, phosphorus and their compounds are probably the most significant elements that influence the ROS formation (Fig. 5, Ref. 16). Full Text in PDF www.elis.sk.
Keywords: iron, spleen, EDX microanalysis, electron microscopy, reactive oxygen species.
Year: 2012, Volume: 113, Issue: 4 Page From: 214, Page To: 216
doi:10.4149/BLL_2012_049


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