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Bratislava Medical Journal 2012 Bratislava Medical Journal Vol.113, No.5, p.270–273, 2012
Bratislava Medical Journal 2012 Bratislava Medical Journal Vol.113, No.5, p.270–273, 2012
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Bratislava Medical Journal Vol.113, No.5, p.270–273, 2012 |
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| Title: The role of nitric oxide on the responses of curcumin-treated rat aorta | ||
| Author: E. K. Atalik, H. Gokbel, M. Oz, N. Okudan, M. Belviranli, H. Esen | ||
| Abstract: Objectives: The aim of the present study was to evaluate the influence of endothelial nitric oxide (NO) on the vascular responses of curcumin-treated rats. Methods: The experimental groups included the control and curcumin-treated (200 mg/kg/day, p.o., for 4 weeks) group. The concentration response curves to receptor-dependent agent 5-hydroxytryptamine (5-HT; 10-–3x10- M) and receptor-independent agent potassium chloride (KCl; 5–100 mM) were observed. Results: The concentration response curves to 5-HT and KCl shifted to the right and the maximal response was significantly decreased in the curcumin-treated rat aortas. A pretreatment of rings with L-NAME (a NOS inhibitor, 10- M) increased both the sensitivity and maximal response to only 5-HT. No apparent histological changes were demonstrated in smooth muscle and connective tissue layers in the aortas of the control and curcumin-treated rat preparations. Conclusion: The results of the present study suggest that NO release from endothelial cells modulates curcumin-treated rat aorta responses to 5-HT, but not to KCl (Tab. 2, Fig. 4, Ref. 25). |
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| Keywords: aorta, curcumine, contractions, serotonin, KCl, nitric oxide. | ||
| Year: 2012, Volume: 113, Issue: 5 | Page From: 270, Page To: 273 | |
| doi:10.4149/BLL_2012_063 |
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