Home Bratislava Medical Journal 2012 Bratislava Medical Journal Vol.113, No.6, p.350–353, 2012

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

Impact factor 1.2

 

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Bratislava Medical Journal Vol.113, No.6, p.350–353, 2012

Title: Protective role of vitamin C in diazepam-induced apoptosis in rat thymocytes
Author: V. Pavlovic, D. Pavlovic, B. Kamenov, M. Sarac, Z. Peric, M. Velojic

Abstract: Abstract: Diazepam, a peripheral-type benzodiazepine receptor ligand, is widely used as a therapeutic agent. On the other hand, peripheral-type benzodiazepines have been shown to induce apoptosis in different immune cell types. In this study, we examined the possible protective role of vitamin C in diazepam-induced apoptosis and evaluated the cellular content of glutathione during this process. Rat thymocytes were incubated for 24 hours with diazepam and increasing concentrations of vitamin C or with diazepam alone. The exposure to diazepam resulted in an increase in apoptotic cell death and decrease in glutathione content in rat thymocytes. Vitamin C was effective in ameliorating the effect of diazepam in rat thymocytes by decreasing the proportion of apoptotic cells and increasing the cellular content of glutathione. These results suggest that vitamin C reduced the diazepam-induced apoptosis in rat thymocytes by restoring the cellular content of glutathione, which may be useful in preventing the diazepam-induced immunosupression (Tab. 1, Fig. 1, Ref. 31).

Keywords: vitamin C, diazepam, thymocytes, apoptosis, glutathione.
Year: 2012, Volume: 113, Issue: 6 Page From: 350, Page To: 353
doi:10.4149/BLL_2012_079


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